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Article

Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome.

Cancer causes & control : CCC - 1 Nov 2009

Chen Jinyun, Etzel Carol J, Amos Christopher I, Zhang Qing, Viscofsky Nancy, Lindor Noralane M, Lynch Patrick M, Frazier Marsha L

Abstract excerpt

PURPOSE: Lynch syndrome is an autosomal dominant syndrome of familial malignancies resulting from germ line mutations in DNA mismatch repair (MMR) genes. Our goal was to take a pathway-based approach to investigate the influence of polymorphisms in cell cycle-related genes on age of onset for Lynch syndrome using a tree model. EXPERIMENTAL DESIGN: We evaluated polymorphisms in a panel of cell cycle-related genes...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis

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Source

Open in PubMed Open full text

Identifiers

PMID: 19690970
DOI: 10.1007/s10552-009-9416-x
PMCID: PMC3917505

Genes

AURKA
IGF1
CCND1
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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