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Article

CYCLIN D1 as a genetic modifier in hereditary nonpolyposis colorectal cancer.

Cancer research - 15 Aug 2001

Bala S, Peltomäki P

Abstract excerpt

Hereditary nonpolyposis colorectal cancer is associated with inherited defects in DNA mismatch repair. Clinical variation even in cases with identical predisposing mutations suggests the existence of other factors contributing to the phenotype. We addressed the modifying role of the common A/G polymorphism in exon 4 and the alternatively spliced transcripts a and b of the CCND1 gene encoding cyclin D1 in a series...

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Share to Adaptor Proteins, Signal Transducing
Share to Alternative Splicing
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin D1

Share to Loss of Heterozygosity

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Source

Identifiers

PMID: 11507050

Genes

CCND1
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CYCLIN D1 as a genetic modifier in hereditary nonpolyposis colorectal cancer.PMID 11507050Read ↗

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Lack of association between CCND1 G870A polymorphism and the risk of breast and colorectal cancers.Semantic proximity Read ↗

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The cyclin D1 alternative transcripts [a] and [b] are expressed in normal and malignant lymphocytes and their relative levels are influenced by the polymorphism at codon 241.Semantic proximity Read ↗

GSTM1 and GSTT1 polymorphisms as modifiers of age at diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) in a homogeneous cohort of individuals carrying a single predisposing mutation.Semantic proximity Read ↗

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