Article
DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2006
Jones J Shawn, Amos Christopher I, Pande Mala, Gu Xiangjun, Chen Jinyun, Campos Imelda M, Wei Qingyi, Rodriguez-Bigas Miguel, Lynch Patrick M, Frazier Marsha L
Abstract excerpt
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant syndrome of familial malignancies resulting from germ-line mutations in DNA mismatch repair genes. Colorectal and endometrial cancers are most frequently observed. A polymorphic C-to-T change in the promoter region of the DNMT3b gene, -149 bp from the transcription start site, is reported to greatly increase promoter activity and is...
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