Article
Interactions between the single nucleotide polymorphisms in the homocysteine pathway (MTHFR 677C>T, MTHFR 1298 A>C, and CBSins) and the efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular disease in high-risk patients of hypertension: the GenHAT study.
Pharmacogenetics and genomics - 1 Aug 2008
Maitland-van der Zee Anke-Hilse, Lynch Amy, Boerwinkle Eric, Arnett Donna K, Davis Barry R, Leiendecker-Foster Catherine, Ford Charles E, Eckfeldt John H
Abstract excerpt
BACKGROUND: High homocysteine blood concentrations predispose to coronary artery disease and statins influence homocysteine levels. AIM: To study whether genes that regulate homocysteine metabolism interact with statins to modify the risk of coronary heart disease (CHD) and other cardiovascular outcomes. METHODS: The Genetics of Hypertension Associated Treatment is an ancillary study of the Antihypertensive and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.