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Article

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis.

BMJ (Clinical research ed.) - 23 Nov 2002

Wald David S, Law Malcolm, Morris Joan K

Abstract excerpt

OBJECTIVE: To assess whether the association of serum homocysteine concentration with ischaemic heart disease, deep vein thrombosis and pulmonary embolism, and stroke is causal and, if so, to quantify the effect of homocysteine reduction in preventing them. DESIGN: Meta-analyses of the above three diseases using (a) 72 studies in which the prevalence of a mutation in the MTHFR gene (which increases homocysteine)...

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Source

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Identifiers

PMID: 12446535
DOI: 10.1136/bmj.325.7374.1202
PMCID: PMC135491

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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