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Homocysteine and Stroke Risk: Modifying Effect of Methylenetetrahydrofolate Reductase C677T Polymorphism and Folic Acid Intervention.

Stroke - 1 May 2017

Zhao Min, Wang Xiaobin, He Mingli, Qin Xianhui, Tang Genfu, Huo Yong, Li Jianping, Fu Jia, Huang Xiao, Cheng Xiaoshu, Wang Binyan, Hou Fan Fan, Sun Ningling, Cai Yefeng

Abstract excerpt

BACKGROUND AND PURPOSE: Elevated blood homocysteine concentration increases the risk of stroke, especially among hypertensive individuals. Homocysteine is largely affected by the methylenetetrahydrofolate reductase C677T polymorphism and folate status. Among hypertensive patients, we aimed to test the hypothesis that the association between homocysteine and stroke can be modified by the methylenetetrahydrofolate...

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Source

Identifiers

PMID: 28360116
DOI: 10.1161/STROKEAHA.116.015324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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