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Article

MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.

JAMA - 1 Jan 2000

Klerk Mariska, Verhoef Petra, Clarke Robert, Blom Henk J, Kok Frans J, Schouten Evert G

Abstract excerpt

CONTEXT: In observational studies, individuals with elevated levels of plasma homocysteine tend to have moderately increased risk of coronary heart disease (CHD). The MTHFR 677C-->T polymorphism is a genetic alteration in an enzyme involved in folate metabolism that causes elevated homocysteine concentrations, but its relevance to risk of CHD is uncertain. OBJECTIVE: To assess the relation of MTHFR 677C-->T...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

Identifiers

PMID: 12387655
DOI: 10.1001/jama.288.16.2023

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.PMID 12387655Read ↗

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