Article
Homocysteine, 5,10-methylenetetrahydrofolate reductase 677C>T polymorphism, nutrient intake, and incident cardiovascular disease in 24,968 initially healthy women.
Clinical chemistry - 1 May 2007
Zee Robert Y L, Mora Samia, Cheng Suzanne, Erlich Henry A, Lindpaintner Klaus, Rifai Nader, Buring Julie E, Ridker Paul M
Abstract excerpt
BACKGROUND: Hyperhomocysteinemia has been associated with a higher risk of cardiovascular disease (CVD) in epidemiological studies, but recent trials have failed to show a benefit of lowering homocysteine. To address this apparent paradox, we explored whether interaction between genetic and dietary factors related to homocysteine metabolism contributes to CVD risk. METHODS: We evaluated the associations of...
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