Article
Genetic and environmental influences on plasma homocysteine: results from a Danish twin study.
Clinical chemistry - 1 May 2007
Bathum Lise, Petersen Inge, Christiansen Lene, Konieczna Agnieszka, Sørensen Thorkild I A, Kyvik Kirsten O
Abstract excerpt
BACKGROUND: Increased plasma homocysteine has been linked to many clinical conditions including atherosclerosis and ischemic stroke. We assessed the genetic and environmental influences on homocysteine in adult twins and tested the influence of 3 candidate polymorphisms. METHODS: Homocysteine was analyzed in 1206 healthy twins, who were genotyped for 3 polymorphisms: MTHFR 677C>T, MTR 2756A>G, and NNMT (dbSNP:...
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