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Article

Homocysteine and stroke: evidence on a causal link from mendelian randomisation.

Lancet (London, England) - 1 Jan 2000

Casas Juan P, Bautista Leonelo E, Smeeth Liam, Sharma Pankaj, Hingorani Aroon D

Abstract excerpt

BACKGROUND: Individuals homozygous for the T allele of the MTHFR C677T polymorphism have higher plasma homocysteine concentrations (the phenotype) than those with the CC genotype, which, if pathogenetic, should put them at increased risk of stroke. Since this polymorphism is distributed randomly during gamete formation, its association with stroke should not be biased or confounded. We investigated consistency...

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Source

Identifiers

PMID: 15652605
DOI: 10.1016/S0140-6736(05)17742-3

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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