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Article

Requirement of estrogen receptor expression and function for [12Val] K-Ras-mediated NIH3T3 cell transformation.

Oncology - 1 Dec 1998

Kato K, Sakamoto T, Wake N

Abstract excerpt

We investigated the biological significance of estrogen receptors (ERs) in NIH3T3 cell transformation by the [12Val] K-Ras mutant. This mutant enhanced the steady-level and transcriptional activity of ER. Coexpression of the progesterone receptor with mutant K-Ras led to suppression of tumorigeni...

Topics

Cell Transformation, Neoplastic
Endometrial Neoplasms
Female
Gene Expression Regulation, Neoplastic
Humans
Mutation
Phenotype
Proto-Oncogene Proteins p21(ras)
Receptors, Estrogen
Receptors, Progesterone
Transcription Factors
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Valine

Source

Identifiers

PMID: 9852401
DOI: 10.1159/000055258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9852401-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Requirement of estrogen receptor expression and function for [12Val] K-Ras-mediated NIH3T3 cell transformation.PMID 9852401Read ↗

Contribution of enhanced transcriptional activation by ER to [12Val] K-Ras mediated NIH3T3 cell transformation.Semantic proximity Read ↗

[Regulation of [12Asp]K-ras4B on transcriptional activity of estrogen receptor in endometrial carcinoma HEC-1A cell lines].Semantic proximity Read ↗

Suppression of ras oncogene-mediated transformation.Semantic proximity Read ↗

Affinity with Raf is sufficient for Ras to efficiently induce rat mammary carcinomas.Semantic proximity Read ↗

R-Ras is regulated by activators and effectors distinct from those that control Ras function.Semantic proximity Read ↗

Altered post-translational processing of p21ras oncoprotein in a transformation-suppressed cell line.Semantic proximity Read ↗

Requirement of Ras-dependent pathways for activation of the transforming growth factor beta3 promoter by estradiol.Semantic proximity Read ↗

Increased tyrosine phosphorylation in ras transformed fibroblasts occurs prior to manifestation of the transformed phenotype.Semantic proximity Read ↗

Persistent estrogen responsiveness of ras oncogene-transformed mouse mammary epithelial cells.Semantic proximity Read ↗

Overexpression of mitogen-activated protein kinase superfamily proteins unrelated to Ras and AF-1 of estrogen receptor alpha mutation in advanced stage human breast cancer.Semantic proximity Read ↗

K-ras activation in neoplasms of the human female reproductive tract.Semantic proximity Read ↗

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