The p21 ras C-terminus is required for transformation and membrane association.

doi:10.1038/310583a0

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Article

The p21 ras C-terminus is required for transformation and membrane association.

Nature - 1 Jan 2000

Willumsen B M, Christensen A, Hubbert N L, Papageorge A G, Lowy D R

Abstract excerpt

The Harvey murine sarcoma virus (Ha-MuSV) transforming gene, v-rasH, encodes a 21,000 molecular weight protein (p21) that is closely related to the p21 proteins encoded by the cellular transforming genes of the ras gene family. The primary translation product (prop21), which is found in the cytos...

Topics

Animals
Base Sequence
Cell Transformation, Neoplastic
Cells, Cultured
Chromosome Deletion
DNA Restriction Enzymes
Genes
Genes, Viral
Harvey murine sarcoma virus
Mice
Mice, Inbred Strains
Molecular Weight
Mutation
Neoplasm Proteins
Oncogenes
Plasmids
Sarcoma Viruses, Murine
Simplexvirus

Source

Open in PubMed

Identifiers

PMID: 6087162
DOI: 10.1038/310583a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-6087162-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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