Article
Abnormal embryonic lymphatic vessel development in Tie1 hypomorphic mice.
Development (Cambridge, England) - 1 Apr 2010
Qu Xianghu, Tompkins Kevin, Batts Lorene E, Puri Mira, Baldwin H Scott, Baldwin Scott
Abstract excerpt
Tie1 is an endothelial receptor tyrosine kinase that is essential for development and maintenance of the vascular system; however, the role of Tie1 in development of the lymphatic vasculature is unknown. To address this question, we first documented that Tie1 is expressed at the earliest stages of lymphangiogenesis in Prox1-positive venous lymphatic endothelial cell (LEC) progenitors. LEC Tie1 expression is...
Topics
- Animals
- Apoptosis
- Blood Vessels
- DNA Primers
- DNA Probes
- Embryonic Development
- Gene Expression Regulation, Developmental
- In Situ Hybridization
- Lymphangiogenesis
- Lymphatic System
- Mice
- Mice, Knockout
- Mice, Mutant Strains
- Phenotype