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Article

Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis.

Blood - 30 Jul 2009

Wei Guo, Srinivasan Ruchika, Cantemir-Stone Carmen Z, Sharma Sudarshana M, Santhanam Ramasamy, Weinstein Michael, Muthusamy Natarajan, Man Albert K, Oshima Robert G, Leone Gustavo, Ostrowski Michael C

Abstract excerpt

The ras/Raf/Mek/Erk pathway plays a central role in coordinating endothelial cell activities during angiogenesis. Transcription factors Ets1 and Ets2 are targets of ras/Erk signaling pathways that have been implicated in endothelial cell function in vitro, but their precise role in vascular formation and function in vivo remains ill-defined. In this work, mutation of both Ets1 and Ets2 resulted in embryonic...

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Identifiers

PMID: 19411629
DOI: 10.1182/blood-2009-03-211391
PMCID: PMC2721789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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