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Article

Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation.

Circulation research - 16 Apr 2004

Noseda Michela, McLean Graeme, Niessen Kyle, Chang Linda, Pollet Ingrid, Montpetit Rachel, Shahidi Réza, Dorovini-Zis Katerina, Li Linheng, Beckstead Benjamin, Durand Ralph E, Hoodless Pamela A, Karsan Aly

Abstract excerpt

Various studies have identified a critical role for Notch signaling in cardiovascular development. In this and other systems, Notch receptors and ligands are expressed in regions that undergo epithelial-to-mesenchymal transformation. However, there is no direct evidence that Notch activation can induce mesenchymal transdifferentiation. In this study we show that Notch activation in endothelial cells results in...

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Identifiers

PMID: 14988227
DOI: 10.1161/01.RES.0000124300.76171.C9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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