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Article

Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2008

Varadkar Prajakta, Kraman Matthew, Despres Daryl, Ma Ge, Lozier Julie, McCright Brent

Abstract excerpt

Mutations in Notch receptors and their ligands have been identified as the cause of human congenital heart diseases, indicating the importance of the Notch signaling pathway during heart development. In our study, we use Cre-Lox technology to inactivate Notch2 in several cardiac cell lineages to determine the functional requirements for Notch2 during mammalian heart development. Inactivation of Notch2 in cardiac...

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Identifiers

PMID: 18330927
DOI: 10.1002/dvdy.21502

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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