Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus.

International journal of molecular sciences - 14 May 2024

von Hofsten Susannah, Fenton Kristin Andreassen, Pedersen Hege Lynum

Abstract excerpt

The pathogenesis of systemic lupus erythematosus (SLE) is linked to the differential roles of toll-like receptors (TLRs), particularly TLR7, TLR8, and TLR9. TLR7 overexpression or gene duplication, as seen with the Y-linked autoimmune accelerator (Yaa) locus or TLR7 agonist imiquimod, correlates with increased SLE severity, and specific TLR7 polymorphisms and gain-of-function variants are associated with enhanced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lupus Erythematosus, Systemic

Share to Toll-Like Receptor 7

Share to Toll-Like Receptor 8

Share to Toll-Like Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 38791389
DOI: 10.3390/ijms25105351
PMCID: PMC11120885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus.PMID 38791389Read ↗

Toll-like receptors in systemic lupus erythematosus: potential for personalized treatmentSemantic proximity Read ↗

Monogenic autoimmunity caused by TLR7 gain-of-functionSemantic proximity Read ↗

Role for toll-like receptors in autoimmune disease: the example of systemic lupus erythematosus.Semantic proximity Read ↗

Molecular and Cellular Mechanisms of Systemic Autoimmune Diseases: Lessons Learned from Human Genetic Studies and Therapies in Systemic Lupus Erythematosus (SLE)Semantic proximity Read ↗

New insights into the immunopathogenesis of systemic lupus erythematosus.Semantic proximity Read ↗

Recent insights into the role of innate immunity in lupusSemantic proximity Read ↗

Immunopathogenesis of systemic lupus erythematosus: An update.Semantic proximity Read ↗

Genetics of SLE: mechanistic insights from monogenic disease and disease-associated variants.Semantic proximity Read ↗

Yaa autoimmune phenotypes are conferred by overexpression of TLR7.Semantic proximity Read ↗

Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of LupusSemantic proximity Read ↗

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus ErythematosusSemantic proximity Read ↗

Mendelian Causes of Autoimmunity: the Lupus Phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.