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Article

Sustained NPSLE-like phenotype in the absence of systemic lupus-like disease in TLR7-deficient B6.Nba2 mice.

Brain, behavior, and immunity - 1 Aug 2025

Kwun Audrey, Sullivan James K, Shelestak John, Merritt Kayla M, Liu Selena S, Mey Gabrielle, DeSilva Tara, Jørgensen Trine N

Abstract excerpt

OBJECTIVE: To investigate the role of Toll-like Receptor 7 (TLR7) in the development of neuropsychiatric lupus (NPSLE) in the B6.Nba2 murine model of SLE. METHODS: TLR7-deficient B6.Nba2 mice were evaluated for the development of NPSLE symptoms through behavioral testing with comparison groups of wild-type NPSLE-prone B6.Nba2 and B6 controls. Behavioral testing results were evaluated in the context of biomarker...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40239904
DOI: 10.1016/j.bbi.2025.04.017
PMCID: PMC13250803

Genes

TLR7
TLR4
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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