Article
The 'zinc knuckle' motif of Early B cell Factor is required for transcriptional activation of B cell-specific genes.
Molecular immunology - 1 Aug 2008
Fields Scott, Ternyak Kristina, Gao Hua, Ostraat Rachel, Akerlund Janie, Hagman James
Abstract excerpt
Early B cell factor (EBF) is a critical regulator of B lymphocyte-specific gene transcription. EBF functions, in part, by binding to regulatory sites of genes required for the pre-B- and mature B cell receptors. These DNA targets include the promoters of the mb-1 and Vpreb1 genes that encode Ig-alpha and one of the components of surrogate light chain, respectively. The biochemical basis of DNA binding and gene...
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