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EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene

22 Feb 2021

Abstract excerpt

Genes encoding B lineage-restricted transcription factors are frequently mutated in B-lymphoid leukemias, suggesting a close link between normal and malignant B-cell development. One of these transcription factors is early B-cell factor 1 (EBF1), a protein of critical importance for lineage specification and survival of B-lymphoid progenitors. Here, we report that impaired EBF1 function in mouse B-cell...

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PMID: 33619557
DOI: 10.1182/blood.2020009564

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