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Article

Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins.

Genes & development - 15 Oct 2010

Treiber Nora, Treiber Thomas, Zocher Georg, Grosschedl Rudolf

Abstract excerpt

Early B-cell factor 1 (Ebf1) is a key transcriptional determinant of B-lymphocyte differentiation whose DNA-binding domain has no sequence similarity to other transcription factor families. Here we report the crystal structure of an Ebf1 dimer bound to its palindromic recognition site. The DNA-binding domain adopts a pseudoimmunoglobulin-like fold with novel topology, but is structurally similar to the Rel...

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Identifiers

PMID: 20876732
DOI: 10.1101/gad.1976610
PMCID: PMC2956205

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Source receipt: pubmed, retrieved 7 Sept 2026.

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