Article
Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter.
Molecular and cellular biology - 1 Dec 2002
Sigvardsson Mikael, Clark Dawn R, Fitzsimmons Daniel, Doyle Michelle, Akerblad Peter, Breslin Thomas, Bilke Sven, Li Ronggui, Yeamans Carmen, Zhang Gongyi, Hagman James
Abstract excerpt
Previous studies have suggested that the early-B-cell-specific mb-1(Igalpha) promoter is regulated by EBF and Pax-5. Here, we used in vivo footprinting assays to detect occupation of binding sites in endogenous mb-1 promoters at various stages of B-cell differentiation. In addition to EBF and Pax-5 binding sites, we detected occupancy of a consensus binding site for E2A proteins (E box) in pre-B cells. EBF and E...
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