Article
Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design.
Genes & development - 1 Jun 1993
Vinson C R, Hai T, Boyd S M
Abstract excerpt
We propose an interhelical salt bridge rule to explain the dimerization specificity between the two amphipathic alpha-helices in the leucine zipper structure. Using the bZIP class of DNA-binding proteins as a model system, we predicted and designed novel dimerization partners. We predicted that A...
Topics
- Activating Transcription Factor 4
- Activating Transcription Factors
- Amino Acid Sequence
- Animals
- Basic-Leucine Zipper Transcription Factors
- Blood Proteins
- Cyclic AMP Response Element-Binding Protein
- DNA
- DNA-Binding Proteins
- G-Box Binding Factors
- Leucine Zippers
- Lymphokines
- Mammals
- Molecular Sequence Data
- Mutation
- Plant Proteins
- Prostatic Secretory Proteins
- Transcription Factors