Understanding the thermostability and activity of Bacillus subtilis lipase mutants: insights from molecular dynamics simulations.

Abstract excerpt

Improving the thermostability of industrial enzymes is an important protein engineering challenge. Point mutations, induced to increase thermostability, affect the structure and dynamics of the target protein in several ways and thus can also affect its activity. There appears to be no general rules for improving the thermostabilty of enzymes without adversely affecting their enzymatic activity. We report MD...

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