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Article

Basic science and clinical research advances in the pituitary transcription factors: Pit-1 and Prop-1.

Current opinion in endocrinology, diabetes, and obesity - 1 Aug 2008

Kerr Janice, Wood William, Ridgway Eli Chester

Abstract excerpt

PURPOSE OF REVIEW: The pituitary-specific transcription factors, Pit-1 (also called Pou1f1) and prophet of Pit-1 (Prop-1), are critical for normal pituitary development and function. The aim of the present review is to highlight the recent basic science and clinical research advances in these transcription factors, as they relate to signaling pathway interactions, gene regulation, and mutations in human diseases....

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Identifiers

PMID: 18594277
DOI: 10.1097/MED.0b013e3283060a56

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Basic science and clinical research advances in the pituitary transcription factors: Pit-1 and Prop-1.PMID 18594277Read ↗

Transcription factors regulating pituitary development.Semantic proximity Read ↗

POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease*Semantic proximity Read ↗

Combined pituitary hormone deficiency: role of Pit-1 and Prop-1.Semantic proximity Read ↗

Pituitary development: a complex, temporal regulated process dependent on specific transcriptional factors.Semantic proximity Read ↗

TCF and Groucho-Related Genes Influence Pituitary Growth and DevelopmentSemantic proximity Read ↗

Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency.Semantic proximity Read ↗

[The pituitary specific transcription factor Pit-1/GHF-1 and PIT1 abnormality].Semantic proximity Read ↗

GH transcription factors.Semantic proximity Read ↗

PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cellsSemantic proximity Read ↗

A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.Semantic proximity Read ↗

Conserved amino acid sequences confer nuclear localization upon the Prophet of Pit-1 pituitary transcription factor protein.Semantic proximity Read ↗

All Hormone-Producing Cell Types of the Pituitary Intermediate and Anterior Lobes Derive From Prop1-Expressing Progenitors.Semantic proximity Read ↗

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