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Article

Combined pituitary hormone deficiency: role of Pit-1 and Prop-1.

Acta paediatrica (Oslo, Norway : 1992). Supplement - 1 Dec 1999

Pfäffle R W, Blankenstein O, Wüller S, Kentrup H

Abstract excerpt

During fetal development of the anterior pituitary gland, a number of sequential processes occur that affect cell differentiation and proliferation. Molecular analyses have revealed several steps that are required for pituitary cell line specification and have identified specific factors that control these steps. The gene encoding the pituitary transcription factor 1 (Pit-1) is expressed during differentiation...

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Source

Identifiers

PMID: 10626543
DOI: 10.1111/j.1651-2227.1999.tb14401.x

Genes

PRL
PROP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Combined pituitary hormone deficiency: role of Pit-1 and Prop-1.PMID 10626543Read ↗

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Familial combined pituitary hormone deficiency due to a novel mutation R99Q in the hot spot region of Prophet of Pit-1 presenting as constitutional growth delay.Semantic proximity Read ↗

GH and TSH deficiency.Semantic proximity Read ↗

Basic science and clinical research advances in the pituitary transcription factors: Pit-1 and Prop-1.Semantic proximity Read ↗

A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.Semantic proximity Read ↗

Impaired Adrenocorticotropin-Adrenal Axis in Combined Pituitary Hormone Deficiency Caused by a Two-Base Pair Deletion (301–302delAG) in the Prophet of Pit-1 Gene<sup>1</sup>Semantic proximity Read ↗

Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility.Semantic proximity Read ↗

Long-term follow-up of combined pituitary hormone deficiency in two siblings with a Prophet of Pit-1 gene mutation.Semantic proximity Read ↗

"Hot Spot" in the PROP1 Gene Responsible for Combined Pituitary Hormone DeficiencySemantic proximity Read ↗

All Hormone-Producing Cell Types of the Pituitary Intermediate and Anterior Lobes Derive From Prop1-Expressing Progenitors.Semantic proximity Read ↗

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