Article
Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency.
Minerva endocrinologica - 1 Jun 2003
Rodriguez R, Andersen B
Abstract excerpt
In the anterior pituitary gland, five distinct hormone producing cell types are generated from common epithelial progenitor cells. This process of cellular determination is controlled by signaling molecules acting on transcription factors, which in turn regulate genes critical for the appearance of hormone producing cells. Two pituitary specific transcription factors, Pit-1 and Prop-1, which are required for...
Topics
- DNA-Binding Proteins
- Gene Frequency
- Homeodomain Proteins
- Human Growth Hormone
- Humans
- Mutation
- Pituitary Diseases
- Pituitary Gland, Anterior
- Transcription Factor Pit-1
- Transcription Factors