Article
[The pituitary specific transcription factor Pit-1/GHF-1 and PIT1 abnormality].
Rinsho byori. The Japanese journal of clinical pathology - 1 Jul 1997
Tatsumi K, Amino N
Abstract excerpt
Pit-1/GHF-1 is a pituitary specific POU-domain DNA binding factor, which transactivates the growth hormone (GH), prolactin (PRL), thyrotropin beta subunit (TSH beta) genes, and PIT1 gene itself. It is indispensable for the differentiation and the proliferation of the cells producing GH, and PRL....
Topics
- Animals
- DNA-Binding Proteins
- Genotype
- Human Growth Hormone
- Humans
- Pituitary Diseases
- Prolactin
- Thyrotropin
- Transcription Factor Pit-1
- Transcription Factors
- Transcriptional Activation