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Article

[The pituitary specific transcription factor Pit-1/GHF-1 and PIT1 abnormality].

Rinsho byori. The Japanese journal of clinical pathology - 1 Jul 1997

Tatsumi K, Amino N

Abstract excerpt

Pit-1/GHF-1 is a pituitary specific POU-domain DNA binding factor, which transactivates the growth hormone (GH), prolactin (PRL), thyrotropin beta subunit (TSH beta) genes, and PIT1 gene itself. It is indispensable for the differentiation and the proliferation of the cells producing GH, and PRL. Loss of the PIT1 gene function (PIT1 abnormality) results in combined deficiency of GH, PRL, and TSH. PIT1 abnormality...

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Source

Identifiers

PMID: 9256012

Genes

PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[From gene to disease; POU1F1- and PROP1-mutations in pituitary hormone deficiency].Semantic proximity Read ↗

A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.Semantic proximity Read ↗

Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency.Semantic proximity Read ↗

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