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Article

A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.

Science (New York, N.Y.) - 21 Aug 1992

Radovick S, Nations M, Du Y, Berg L A, Weintraub B D, Wondisford F E

Abstract excerpt

Pit-1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals. Mutations in the gene encoding Pit-1 have been found in two dwarf mouse strains displaying hypoplasia of growth hormone, prolactin, and thyroid-stimulating, hormone-secreting cell types in the anterior pituitary. A point mutation in this gene was identified on one allele in a patient with...

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Identifiers

PMID: 1509262
DOI: 10.1126/science.257.5073.1115

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A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.PMID 1509262Read ↗

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.Semantic proximity Read ↗

A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone deficiency.Semantic proximity Read ↗

Combined pituitary hormone deficiency: role of Pit-1 and Prop-1.Semantic proximity Read ↗

Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency.Semantic proximity Read ↗

Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency.Semantic proximity Read ↗

[From gene to disease; POU1F1- and PROP1-mutations in pituitary hormone deficiency].Semantic proximity Read ↗

Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia.Semantic proximity Read ↗

Basic science and clinical research advances in the pituitary transcription factors: Pit-1 and Prop-1.Semantic proximity Read ↗

POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease*Semantic proximity Read ↗

Combined pituitary hormone deficiency caused by compound heterozygosity for two novel mutations in the POU domain of the Pit1/POU1F1 gene.Semantic proximity Read ↗

A novel mutation in PIT-1: phenotypic variability in familial combined pituitary hormone deficiencies.Semantic proximity Read ↗

Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin.Semantic proximity Read ↗

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