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TCF and Groucho-Related Genes Influence Pituitary Growth and Development

12 Aug 2003

Abstract excerpt

Mutations in the prophet of PIT1 gene (PROP1) are the most common cause of multiple pituitary hormone deficiency in humans; however, the mechanism of PROP1 action is not well understood. We report that Prop1 is essential for dorsally restricted expression of a Groucho-related gene, transducin-like enhancer of split 3 (Tle3), which encodes a transcriptional corepressor. Deficiency of a related gene, amino terminal...

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Identifiers

PMID: 12907761
DOI: 10.1210/me.2003-0225

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