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Article

Pituitary development: a complex, temporal regulated process dependent on specific transcriptional factors.

The Journal of endocrinology - 1 Nov 2012

de Moraes Débora Cristina, Vaisman Mario, Conceição Flavia Lucia, Ortiga-Carvalho Tânia Maria

Abstract excerpt

Pituitary organogenesis is a highly complex and tightly regulated process that depends on several transcription factors (TFs), such as PROP1, PIT1 (POU1F1), HESX1, LHX3 and LHX4. Normal pituitary development requires the temporally and spatially organised expression of TFs and interactions between different TFs, DNA and TF co-activators. Mutations in these genes result in different combinations of hypopituitarism...

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Source

Identifiers

PMID: 22872762
DOI: 10.1530/JOE-12-0229

Genes

HESX1
LHX3
LHX4
PROP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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