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Article

Transporter-mediated protection against thiopurine-induced hematopoietic toxicity.

Cancer research - 1 Jul 2008

Krishnamurthy Partha, Schwab Matthias, Takenaka Kazumasa, Nachagari Deepa, Morgan Jessica, Leslie Mark, Du Weinan, Boyd Kelli, Cheok Meyling, Nakauchi Hiromitsu, Marzolini Catia, Kim Richard B, Poonkuzhali Balasubramanian, Schuetz Erin, Evans William, Relling Mary, Schuetz John D

Abstract excerpt

Thiopurines are effective immunosuppressants and anticancer agents, but intracellular accumulation of their active metabolites (6-thioguanine nucleotides, 6-TGN) causes dose-limiting hematopoietic toxicity. Thiopurine S-methyltransferase deficiency is known to exacerbate thiopurine toxicity. However, many patients are highly sensitive to thiopurines for unknown reasons. We show that multidrug-resistance protein 4...

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Identifiers

PMID: 18593894
DOI: 10.1158/0008-5472.CAN-07-6790
PMCID: PMC3323115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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