The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease.

doi:10.1007/s00535-010-0248-y

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Article

The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease.

Journal of gastroenterology - 1 Oct 2010

Ban Hiromistu, Andoh Akira, Imaeda Hirotsugu, Kobori Ayako, Bamba Shigeki, Tsujikawa Tomoyuki, Sasaki Masaya, Saito Yasuharu, Fujiyama Yoshihide

Abstract excerpt

BACKGROUND: Multidrug resistance protein 4 (MRP4) functions as an efflux pump of nucleoside monophosphate analogs, such as 6-mercaptopurine (6-MP) and 6-thioguanine nucleotide (6-TGN). A single-nucleotide polymorphism in human MRP4 (rs3765534) dramatically reduces MRP4 function and results in the intracellular accumulation of 6-TGN. In this study, we investigated the association between MRP4 G2269A polymorphism...

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PMID: 20393862
DOI: 10.1007/s00535-010-0248-y

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TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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