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Article

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

6 Jun 2000

Abstract excerpt

Two prominent members of the ATP-binding cassette superfamily of transmembrane proteins, multidrug resistance 1 (MDR1) P-glycoprotein and multidrug resistance protein 1 (MRP1), can mediate the cellular extrusion of xenobiotics and (anticancer) drugs from normal and tumor cells. The MRP subfamily consists of at least six members, and here we report the functional characterization of human MRP5. We found resistance...

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PMID: 10840050
DOI: 10.1073/pnas.120159197

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