Article
Structure of the CLC-1 chloride channel from Homo sapiens.
eLife - 29 May 2018
Park Eunyong, MacKinnon Roderick
Abstract excerpt
CLC channels mediate passive Cl- conduction, while CLC transporters mediate active Cl- transport coupled to H+ transport in the opposite direction. The distinction between CLC-0/1/2 channels and CLC transporters seems undetectable by amino acid sequence. To understand why they are different functionally we determined the structure of the human CLC-1 channel. Its 'glutamate gate' residue, known to mediate proton...
Topics
- Amino Acid Substitution
- Chloride Channels
- Chlorides
- Glutamic Acid
- Humans
- Ion Channel Gating
- Models, Molecular
- Mutation
- Protein Conformation