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Article

Chloride dependence of hyperpolarization-activated chloride channel gates.

The Journal of physiology - 1 Mar 1999

Pusch M, Jordt S E, Stein V, Jentsch T J

Abstract excerpt

1. ClC proteins are a class of voltage-dependent Cl- channels with several members mutated in human diseases. The prototype ClC-0 Torpedo channel is a dimeric protein; each subunit forms a pore that can gate independently from the other one. A common slower gating mechanism acts on both pores simultaneously; slow gating activates ClC-0 at hyperpolarized voltages. The ClC-2 Cl- channel is also activated by...

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Identifiers

PMID: 10050002
DOI: 10.1111/j.1469-7793.1999.341ac.x
PMCID: PMC2269146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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