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Article

Insights into CLC-0's Slow-Gating from Intracellular Proton Inhibition.

International journal of molecular sciences - 16 Jul 2024

Kwon Hwoi Chan, Fairclough Robert H, Chen Tsung-Yu

Abstract excerpt

The opening of the Torpedo CLC-0 chloride (Cl-) channel is known to be regulated by two gating mechanisms: fast gating and slow (common) gating. The structural basis underlying the fast-gating mechanism is better understood than that of the slow-gating mechanism, which is still largely a mystery. Our previous study on the intracellular proton (H+i)-induced inhibition of the CLC-0 anionic current led to the...

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Identifiers

PMID: 39063037
DOI: 10.3390/ijms25147796
PMCID: PMC11276645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Insights into CLC-0's Slow-Gating from Intracellular Proton Inhibition.PMID 39063037Read ↗

Proton-dependent inhibition, inverted voltage activation, and slow gating of CLC-0 Chloride Channel.Semantic proximity Read ↗

Intracellular proton regulation of ClC-0.Semantic proximity Read ↗

The role of protons in fast and slow gating of the Torpedo chloride channel ClC-0.Semantic proximity Read ↗

Analysis of a protein region involved in permeation and gating of the voltage-gated Torpedo chloride channel ClC-0.Semantic proximity Read ↗

Temperature dependence of fast and slow gating relaxations of ClC-0 chloride channels.Semantic proximity Read ↗

Proton sensing of CLC-0 mutant E166D.Semantic proximity Read ↗

Modulation of the slow/common gating of CLC channels by intracellular cadmium.Semantic proximity Read ↗

Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain.Semantic proximity Read ↗

Chloride dependence of hyperpolarization-activated chloride channel gates.Semantic proximity Read ↗

Determinants of slow gating in ClC-0, the voltage-gated chloride channel of Torpedo marmorata.Semantic proximity Read ↗

Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion.Semantic proximity Read ↗

Two physically distinct pores in the dimeric ClC-0 chloride channel.Semantic proximity Read ↗

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