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Article

Ion transit pathways and gating in ClC chloride channels.

Proteins - 1 Nov 2004

Yin Jian, Kuang Zhifeng, Mahankali Uma, Beck Thomas L

Abstract excerpt

ClC chloride channels possess a homodimeric structure in which each monomer contains an independent chloride ion pathway. ClC channel gating is regulated by chloride ion concentration, pH and voltage. Based on structural and physiological evidence, it has been proposed that a glutamate residue on the extracellular end of the selectivity filter acts as a fast gate. We utilized a new search algorithm that...

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Identifiers

PMID: 15340928
DOI: 10.1002/prot.20208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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