Analysis of a protein region involved in permeation and gating of the voltage-gated Torpedo chloride channel ClC-0.

Abstract excerpt

1. The chloride channel from the Torpedo electric organ, ClC-0, is controlled by two distinct ('fast' and 'slow') voltage-dependent gates. Here we investigate the effects of mutations in a region after putative transmembrane domain D12. A mutation in this region has previously been shown to change fast gating and permeation. 2. We used a combination of site-directed mutagenesis with two-electrode voltage-clamp...

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