Article
Analysis of a protein region involved in permeation and gating of the voltage-gated Torpedo chloride channel ClC-0.
The Journal of physiology - 1 Feb 1997
Ludewig U, Jentsch T J, Pusch M
Abstract excerpt
1. The chloride channel from the Torpedo electric organ, ClC-0, is controlled by two distinct ('fast' and 'slow') voltage-dependent gates. Here we investigate the effects of mutations in a region after putative transmembrane domain D12. A mutation in this region has previously been shown to chang...
Topics
- Animals
- Cell Membrane Permeability
- Chloride Channels
- Electric Organ
- Electric Stimulation
- Electrophysiology
- Ion Channel Gating
- Membrane Potentials
- Mutagenesis
- Mutation
- Patch-Clamp Techniques
- Proteins