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Article

Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion.

Nature - 9 Feb 1995

Pusch M, Ludewig U, Rehfeldt A, Jentsch T J

Abstract excerpt

Chloride channels of the ClC family are important for the control of membrane excitability, cell volume regulation, and possibly transepithelial transport. Although lacking the typical voltage-sensor found in cation channels, gating of ClC channels is clearly voltage-dependent. For the prototype Torpedo channel ClC-0 (refs 11-15) we now show that channel opening is strongly facilitated by external chloride. Other...

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Source

Identifiers

PMID: 7845466
DOI: 10.1038/373527a0

Genes

CIC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion.PMID 7845466Read ↗

Analysis of a protein region involved in permeation and gating of the voltage-gated Torpedo chloride channel ClC-0.Semantic proximity Read ↗

Intracellular proton regulation of ClC-0.Semantic proximity Read ↗

Chloride dependence of hyperpolarization-activated chloride channel gates.Semantic proximity Read ↗

Two physically distinct pores in the dimeric ClC-0 chloride channel.Semantic proximity Read ↗

Proton sensing of CLC-0 mutant E166D.Semantic proximity Read ↗

The role of protons in fast and slow gating of the Torpedo chloride channel ClC-0.Semantic proximity Read ↗

Amazing chloride channels: an overview.Semantic proximity Read ↗

Insights into CLC-0's Slow-Gating from Intracellular Proton Inhibition.Semantic proximity Read ↗

Inward rectification in ClC-0 chloride channels caused by mutations in several protein regions.Semantic proximity Read ↗

Mutations in an intracellular vestibule that bifurcates from the pore of ClC-1 chloride ion channels affect anion permeationSemantic proximity Read ↗

Determinants of slow gating in ClC-0, the voltage-gated chloride channel of Torpedo marmorata.Semantic proximity Read ↗

Structure and function of ClC chloride channels.Semantic proximity Read ↗

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