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Article

Proton-dependent inhibition, inverted voltage activation, and slow gating of CLC-0 Chloride Channel.

PloS one - 1 Jan 2020

Kwon Hwoi Chan, Yu Yawei, Fairclough Robert H, Chen Tsung-Yu

Abstract excerpt

CLC-0, a prototype Cl- channel in the CLC family, employs two gating mechanisms that control its ion-permeation pore: fast gating and slow gating. The negatively-charged sidechain of a pore glutamate residue, E166, is known to be the fast gate, and the swinging of this sidechain opens or closes the pore of CLC-0 on the millisecond time scale. The other gating mechanism, slow gating, operates with much slower...

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Identifiers

PMID: 33362212
DOI: 10.1371/journal.pone.0240704
PMCID: PMC7757909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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