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Article

Extensive degradation of RNA precursors by the exosome in wild-type cells.

Molecular cell - 9 Nov 2012

Gudipati Rajani Kanth, Xu Zhenyu, Lebreton Alice, Séraphin Bertrand, Steinmetz Lars M, Jacquier Alain, Libri Domenico

Abstract excerpt

The exosome is a complex involved in the maturation of rRNA and sn-snoRNA, in the degradation of short-lived noncoding RNAs, and in the quality control of RNAs produced in mutants. It contains two catalytic subunits, Rrp6p and Dis3p, whose specific functions are not fully understood. We analyzed the transcriptome of combinations of Rrp6p and Dis3p catalytic mutants by high-resolution tiling arrays. We show that...

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Source

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Identifiers

PMID: 23000176
DOI: 10.1016/j.molcel.2012.08.018
PMCID: PMC3496076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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