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Article

Yeast Sm-like proteins function in mRNA decapping and decay.

Nature - 30 Mar 2000

Tharun S, He W, Mayes A E, Lennertz P, Beggs J D, Parker R

Abstract excerpt

One of the main mechanisms of messenger RNA degradation in eukaryotes occurs by deadenylation-dependent decapping which leads to 5'-to-3' decay. A family of Sm-like (Lsm) proteins has been identified, members of which contain the 'Sm' sequence motif, form a complex with U6 small nuclear RNA and are required for pre-mRNA splicing. Here we show that mutations in seven yeast Lsm proteins (Lsm1-Lsm7) also lead to...

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Identifiers

PMID: 10761922
DOI: 10.1038/35006676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Yeast Sm-like proteins function in mRNA decapping and decay.PMID 10761922Read ↗

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