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Article

Expression of the adaptor protein Lnk in leukemia cells.

Experimental hematology - 1 May 2009

Gery Sigal, Gueller Saskia, Nowak Verena, Sohn Julia, Hofmann Wolf K, Koeffler H Phillip

Abstract excerpt

OBJECTIVE: Tyrosine kinases are involved in cytokine signaling and are frequently aberrantly activated in hematological malignancies. Lnk, a negative regulator of cytokine signaling, plays critical nonredundant roles in hematopoiesis. By binding to phosphorylated tyrosine kinases, Lnk inhibits major cytokine receptor signaling, including c-KIT; erythropoietin receptor-Janus kinase 2 (JAK2); and MPL-JAK2. In the...

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Topics

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Share to Fusion Proteins, bcr-abl
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Mitogen-Activated Protein Kinase Kinases

Share to Myelodysplastic Syndromes

Share to Proto-Oncogene Proteins c-akt

Share to Proto-Oncogene Proteins c-kit

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 19375649
DOI: 10.1016/j.exphem.2009.01.009

Genes

JAK2
KIT
BCR
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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