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Article

Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.

Blood - 18 Oct 2012

Lin De-Chen, Yin Tong, Koren-Michowitz Maya, Ding Ling-Wen, Gueller Saskia, Gery Sigal, Tabayashi Takayuki, Bergholz Ulla, Kazi Julhash U, Rönnstrand Lars, Stocking Carol, Koeffler H Phillip

Abstract excerpt

Fms-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase with important roles in hematopoietic progenitor cell survival and proliferation. It is mutated in approximately one-third of AML patients, mostly by internal tandem duplications (ITDs). Adaptor protein Lnk is a negative regulator of hematopoietic cytokine signaling. In the present study, we show that Lnk interacts physically with both wild-type FLT3...

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Share to Colony-Forming Units Assay
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cells

Share to Leukemia, Myeloid, Acute

Share to RNA, Small Interfering

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Source

Open in PubMed Open full text

Identifiers

PMID: 22942183
DOI: 10.1182/blood-2011-10-388611
PMCID: PMC3476541

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.PMID 22942183Read ↗

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