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Article

SRC-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformation.

Scientific reports - 23 Apr 2018

Rupar Kaja, Moharram Sausan A, Kazi Julhash U, Rönnstrand Lars

Abstract excerpt

KIT is a receptor tyrosine kinase (RTK) involved in several cellular processes such as regulation of proliferation, survival and differentiation of early hematopoietic cells, germ cells and melanocytes. Activation of KIT results in phosphorylation of tyrosine residues in the receptor, and recruitment of proteins that mediate downstream signaling and also modulate receptor signaling. Here we show that the SRC-like...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Chlorocebus aethiops

Share to COS Cells

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Share to Proto-Oncogene Proteins c-kit

Share to src Homology Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 29686302
DOI: 10.1038/s41598-018-24743-y
PMCID: PMC5913247

Genes

KIT
SRC
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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