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Article

Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK.

Nature communications - 20 Oct 2021

Morris Rhiannon, Zhang Yaoyuan, Ellyard Julia I, Vinuesa Carola G, Murphy James M, Laktyushin Artem, Kershaw Nadia J, Babon Jeffrey J

Abstract excerpt

The SH2B family of adaptor proteins, SH2-B, APS, and LNK are key modulators of cellular signalling pathways. Whilst SH2-B and APS have been partially structurally and biochemically characterised, to date there has been no such characterisation of LNK. Here we present two crystal structures of the LNK substrate recognition domain, the SH2 domain, bound to phosphorylated motifs from JAK2 and EPOR, and biochemically...

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Identifiers

PMID: 34671038
DOI: 10.1038/s41467-021-26394-6
PMCID: PMC8528861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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