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Article

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.

Developmental biology - 1 Aug 2008

Goessling Wolfram, North Trista E, Lord Allegra M, Ceol Craig, Lee Sang, Weidinger Gilbert, Bourque Caitlin, Strijbosch Robbert, Haramis Anna-Pavlina, Puder Mark, Clevers Hans, Moon Randall T, Zon Leonard I

Abstract excerpt

Developmental signaling pathways hold the keys to unlocking the promise of adult tissue regeneration, and to inhibiting carcinogenesis. Patients with mutations in the Adenomatous Polyposis Coli (APC) gene are at increased risk of developing hepatoblastoma, an embryonal form of liver cancer, suggesting that Wnt affects hepatic progenitor cells. To elucidate the role of APC loss and enhanced Wnt activity in liver...

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Source

Identifiers

PMID: 18585699
DOI: 10.1016/j.ydbio.2008.05.526

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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