Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling.

Mechanisms of development - 1 Jan 2000

Varnat Frédéric, Zacchetti Giovanna, Ruiz i Altaba Ariel

Abstract excerpt

Several lines of evidence point to the central role of WNT signaling in the initiation of intestinal tumorigenesis, most often due to loss of APC, a negative regulator of the WNT-betaCATENIN/TCF pathway. Modeling human colon cancers in mice through loss of Apc has shown that inappropriate activation of Wnt signaling is sufficient to induce adenoma formation. More recent analyses have also demonstrated a key role...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to Epithelium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeostasis

Share to Intestinal Mucosa

Share to Intestines

Share to Stem Cells

Share to Tamoxifen

Share to Wnt Proteins

Source

Identifiers

PMID: 19861162
DOI: 10.1016/j.mod.2009.10.005

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling.PMID 19861162Read ↗

Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.Semantic proximity Read ↗

Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice.Semantic proximity Read ↗

Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tractSemantic proximity Read ↗

Wnt signalling in the mouse intestine.Semantic proximity Read ↗

Hedgehog Signaling in Colorectal Cancer: All in the Stroma?Semantic proximity Read ↗

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation.Semantic proximity Read ↗

WNT signaling in the normal intestine and colorectal cancer.Semantic proximity Read ↗

Expression of human GLI in mice results in failure to thrive, early death, and patchy Hirschsprung-like gastrointestinal dilatation.Semantic proximity Read ↗

Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor LesionsSemantic proximity Read ↗

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestineSemantic proximity Read ↗

APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression.Semantic proximity Read ↗

Conserved mechanisms of tumorigenesis in the Drosophila adult midgut.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.