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Article

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.

Genes & development - 15 Jun 2004

Sansom Owen J, Reed Karen R, Hayes Anthony J, Ireland Heather, Brinkmann Hannah, Newton Ian P, Batlle Eduard, Simon-Assmann Patricia, Clevers Hans, Nathke Inke S, Clarke Alan R, Winton Douglas J

Abstract excerpt

Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise mechanism of this suppression remains to be defined. Using a novel inducible Ahcre transgenic line in conjunction with a loxP-flanked Apc allele we, show that loss of Apc acutely activates Wnt signaling through the nuclear accumulation of beta-catenin. Coincidentally, it perturbs differentiation, migration, proliferation,...

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Share to Adenomatous Polyposis Coli Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15198980
DOI: 10.1101/gad.287404
PMCID: PMC423189

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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